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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T10708 | CCR1 antagonist 6 | CCR | |
CCR1 antagonist 6 is a CCR1 antagonist (IC50: 3 nM). | |||
T30258 | AZD-4818 | CCR1 antagonist | CCR |
AZD-4818 (CCR1 antagonist) is a chemokine CCR1 antagonist for the treatment of chronic obstructive pulmonary disease. | |||
T10710 | CCR1 antagonist 9 | CCR | |
CCR1 antagonist 9 is an effective and selective CCR1 antagonist (IC50: 6.8 nM in calcium flux assay). | |||
T14899 | CCR1 antagonist 8 | CCR | |
CCR1 antagonist 8, a third azaindazole series compound, is a CCR1 antagonist (IC50: 1.8 nM in Ca2+ flux assay). | |||
T10709 | CCR1 antagonist 7 | CCR | |
CCR1 antagonist 7 (compound 16r) is an antagonist of chemokine receptor 1 (CCR1) with an IC 50 of 4 nM [1]. | |||
T15253 | CCX354 | CCR1 antagonist 1,CCX-354,CCX 354 | CCR |
CCX354 (CCR1 antagonist 1) is a potent small molecule CCR1 antagonist with anti-inflammatory activity for the treatment of rheumatoid arthritis. | |||
T64242 | CCR1 antagonist 11 hydrochloride | ||
CCR1 antagonist 11 hydrochloride (A1B1) is an orally active CCR1 antagonist that acts on hCCR1 (IC50: 0/.03 μM), mCCR1 (IC50: 0.58 μM), rCCR1 (IC50: 0.32 μM). 11 hydrochloride can be used to study rheumatoid arthritis an... | |||
T28072 | MLN-3897 | AVE9897,AVE 9897,CCR1 antagonist 10,AVE-9897 | CCR |
MLN-3897 (CCR1 antagonist 10) is an orally active antagonist of CCR1 with a Ki of 2.3 nM for 125I-MIP-1α binding to THP-1 cell membranes. MLN-3897 inhibits Akt signaling and MM cell survival and proliferation. | |||
T2375 | BX471 | BX 471,BX-471,ZK-811752 | CCR |
BX471 (BX 471) is a potent, selective non-peptide CCR1 antagonist. | |||
T28072L | MLN-3897 TFA | MLN-3897 TFA(1010731-97-1 Free base) | CCR |
MLN-3897 TFA is a potent CCR1 antagonist that inhibits the binding of 125I-MIP-1α to THP-1 cell membranes. | |||
TQ0283 | RS102895 | CCR | |
RS102895 is a potent CCR2 antagonist (IC50: 360 nM) and shows no effect on CCR1. | |||
T11699 | J-113863 | CCR | |
J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM). J-113863 is inactive against CCR2, CCR4 and CCR5, as well as the LTB4 or TNF-α receptor... | |||
T5384 | RS 504393 | CCR | |
RS 504393 is a highly selective CCR2 chemokine receptor antagonist (IC50s: 89 nM and > 100 μM for human recombinant CCR2 and CCR1). | |||
T26861 | BMS-817399 | BMS817399 | CCR |
BMS-817399 is an orally active antagonist of CCR1 with IC50s of binding affinity and chemotaxis inhibition potencies and can be used in studies about rheumatoid arthritis. | |||
T23492 | UCB 35625 | Others | |
chemokine CCR1 and CCR3 receptor antagonist | |||
T14845 | BX471 hydrochloride | ZK-811752 hydrochloride | Others |
BX471 hydrochloride (ZK-811752 hydrochloride) is a potent, selective non-peptide CCR1 antagonist (Ki: 1 nM for human CCR1). It shows 250-fold selectivity for CCR1 over CCR2, CCR5, and CXCR4. | |||
T31061 | CP-481715 | CP 481,715,CP-481,715,CP481715,CP481,715 | |
CP 481715 is an effective selective CCR1 antagonist with potential therapeutic significance for inflammatory diseases. | |||
T26849 | BMS-457 | ||
BMS-457 is a potent, CCR1-selective antagonist. | |||
T71905 | BX-513 HCl | ||
BX-513 HCl is a selective CCR1 receptor antagonist. | |||
T68427 | MLN-3897 citrate | ||
MLN-3897 citrate is a C-C Motif Chemokine Receptor 1 (CCR1) antagonist potentially for the treatment of multiple sclerosis and rheumatoid arthritis. |